Clinical Studies

1. 9 Osborne R, Mullins L, Robinson L. Topical N-acetyl glucosamine and niacinamide increase hyaluronan in vitro. J Am Acad Dermatol 2006; 54: AB106.

https://www.mattek.com/reference-library/topical-n-acetyl-glucosamine-and-niacinamide-increase-hyaluronan-in-vitro/

2. Weindl G, Schaller M, Schafer-Korting M, Korting HC. Hyaluronic acid in the treatment and prevention of skin diseases: molecular, biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol 2004; 17: 207–13.

https://pubmed.ncbi.nlm.nih.gov/15452406/

3. Sayo T, Sakai S, Inoue S. Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes. Skin Pharmacol Physiol 2004; 17: 77–83.

https://pubmed.ncbi.nlm.nih.gov/14976384/

4. Andre P. Hyaluronic acid and its use as a “rejuvenation” agent in cosmetic dermatology. Semin Cutan Med Surg 2004; 23: 218–22.

https://pubmed.ncbi.nlm.nih.gov/15745228/

5. Fantasia et al, J Am Acad Dermatol, 64(2):AB22, S1,2011

https://www.researchgate.net/publication/283776287_Hexylresorcinol_Providing_Skin_Benefits_by_Modulating_Multiple_Molecular_Targets

6. Traikovich SS. Use of Topical Ascorbic acid and its effects on Photo damaged skin topography. Arch Otorhinol Head Neck Surg 1999;125:1091‐8.

https://pubmed.ncbi.nlm.nih.gov/10522500/

7. Briganti, S et al. (2003) Chemical and Instrumental Approaches to Treat Hyperpigmentation Pigment Cell Res 16:101–110.

https://pubmed.ncbi.nlm.nih.gov/12622786/

8. Humbert PG, Haftek M, Creidi P, et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evalua- tion: double-blind study vs. placebo. Exp Dermatol 2003;12:237–44.

https://pubmed.ncbi.nlm.nih.gov/12823436/

11. Ghersetich I, Lotti T, Campanile G et al. Hyaluronic acid in cutaneous aging. Int J Dermatol 1994; 33: 119–22.

https://pubmed.ncbi.nlm.nih.gov/8157393/

12. Bissett D, Robinson L, Li J, Miyamoto K. Topical N-acetyl glucosamine reduces the appearance of hyperpigmented spots on human facial skin. J Am Acad Dermatol 2006; 54: AB43.

https://pubmed.ncbi.nlm.nih.gov/19845667/

13. (J Am Acad Dermatol, 64(2):AB22, S1,2011)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448221/

14. Ando H, Funasaka Y, Oka M, Ohashi A, Furumura M, Matsunaga J, Matsunaga N, Hearing VJ, Ichihashi M, J Lipid Res, 40:1312-1316, 1999

https://pubmed.ncbi.nlm.nih.gov/10393216/

15. Yen GC, Duh PD, Lin CW, Free Radical Research, 37(5):509-514, 2003]

https://scirp.org/reference/ReferencesPapers.aspx?ReferenceID=163000

17. Corum Internal Report. Feb 2013.

https://protecingredia.com/brochure/Corum-9515.pdf

18. Ref: Petit, L., Pierard, G., Skin-lightening products revisited, Int. J. Cosm. Sc, (2003), 25, 169-181

https://pubmed.ncbi.nlm.nih.gov/18494898/

Clinical Studies

1. 9 Osborne R, Mullins L, Robinson L. Topical N-acetyl glucosamine and niacinamide increase hyaluronan in vitro. J Am Acad Dermatol 2006; 54: AB106.

https://www.mattek.com/reference-library/topical-n-acetyl-glucosamine-and-niacinamide-increase-hyaluronan-in-vitro/

2. Weindl G, Schaller M, Schafer-Korting M, Korting HC. Hyaluronic acid in the treatment and prevention of skin diseases: molecular, biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol 2004; 17: 207–13.

https://pubmed.ncbi.nlm.nih.gov/15452406/

3. Sayo T, Sakai S, Inoue S. Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes. Skin Pharmacol Physiol 2004; 17: 77–83.

https://pubmed.ncbi.nlm.nih.gov/14976384/

4. Andre P. Hyaluronic acid and its use as a “rejuvenation” agent in cosmetic dermatology. Semin Cutan Med Surg 2004; 23: 218–22.

https://pubmed.ncbi.nlm.nih.gov/15745228/

5. Fantasia et al, J Am Acad Dermatol, 64(2):AB22, S1,2011

https://www.researchgate.net/publication/283776287_Hexylresorcinol_Providing_Skin_Benefits_by_Modulating_Multiple_Molecular_Targets

6. Traikovich SS. Use of Topical Ascorbic acid and its effects on Photo damaged skin topography. Arch Otorhinol Head Neck Surg 1999;125:1091‐8.

https://pubmed.ncbi.nlm.nih.gov/10522500/

7. Briganti, S et al. (2003) Chemical and Instrumental Approaches to Treat Hyperpigmentation Pigment Cell Res 16:101–110.

https://pubmed.ncbi.nlm.nih.gov/12622786/

8. Humbert PG, Haftek M, Creidi P, et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evalua- tion: double-blind study vs. placebo. Exp Dermatol 2003;12:237–44.

https://pubmed.ncbi.nlm.nih.gov/12823436/

11. Ghersetich I, Lotti T, Campanile G et al. Hyaluronic acid in cutaneous aging. Int J Dermatol 1994; 33: 119–22.

https://pubmed.ncbi.nlm.nih.gov/8157393/

12. Bissett D, Robinson L, Li J, Miyamoto K. Topical N-acetyl glucosamine reduces the appearance of hyperpigmented spots on human facial skin. J Am Acad Dermatol 2006; 54: AB43.

https://pubmed.ncbi.nlm.nih.gov/19845667/

13. (J Am Acad Dermatol, 64(2):AB22, S1,2011)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448221/

14. Ando H, Funasaka Y, Oka M, Ohashi A, Furumura M, Matsunaga J, Matsunaga N, Hearing VJ, Ichihashi M, J Lipid Res, 40:1312-1316, 1999

https://pubmed.ncbi.nlm.nih.gov/10393216/

15. Yen GC, Duh PD, Lin CW, Free Radical Research, 37(5):509-514, 2003]

https://scirp.org/reference/ReferencesPapers.aspx?ReferenceID=163000

17. Corum Internal Report. Feb 2013.

https://protecingredia.com/brochure/Corum-9515.pdf

18. Ref: Petit, L., Pierard, G., Skin-lightening products revisited, Int. J. Cosm. Sc, (2003), 25, 169-181

https://pubmed.ncbi.nlm.nih.gov/18494898/

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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